Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430613 | 0.86 | MAPT (0.43) | MAPTALDH1A1GAACYP3A4CYP2D6 | |
| SCHEMBL17032294 | 0.84 | ALDH1A1 (0.41) | MAPTALDH1A1GAAKDM4EHSD17B10 | |
| SCHEMBL7030224 | 0.84 | ALDH1A1 (0.41) | MAPTALDH1A1GAAKDM4EHSD17B10 | |
| SCHEMBL17913821 | 0.78 | MAPT (0.43) | MAPTALDH1A1GAACYP3A4CYP2D6 | |
| SCHEMBL17028515 | 0.77 | MAPT (0.45) | MAPTALDH1A1GAACYP3A4CYP2D6 | |
| SCHEMBL17028497 | 0.76 | OPRK1 (0.32) | GAA | |
| SCHEMBL18309979 | 0.76 | ALDH1A1 (0.38) | MAPTALDH1A1CYP3A4PPM1BPTPN1 | |
| SCHEMBL15322838 | 0.75 | MAPT (0.45) | MAPTALDH1A1GAACYP3A4CYP2D6 | |
| SCHEMBL15719400 | 0.75 | MAPT (0.45) | MAPTALDH1A1GAACYP3A4CYP2D6 | |
| SCHEMBL18298200 | 0.74 | GAA (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107914-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015124941-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-08-27 | — | — | WO | disclosed |