Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430563 | 0.83 | HRH4 (0.54) | HRH4CHRNB2CHRNA4CSNK1E | |
| SCHEMBL3433540 | 0.83 | HRH4 (0.44) | HRH4CHRNB2CHRNA4CSNK1E | |
| SCHEMBL15393065 | 0.76 | HRH4 (0.48) | HRH4CHRNB2CHRNA4CSNK1E | |
| SCHEMBL3433510 | 0.72 | HRH4 (0.52) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL3433512 | 0.72 | CHRNB2 (0.51) | HRH4CHRNB2CHRNA4CSNK1E | |
| SCHEMBL603773 | 0.70 | HRH4 (0.54) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL603774 | 0.70 | HRH4 (0.54) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL12137910 | 0.69 | HRH4 (0.48) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL606081 | 0.69 | HRH4 (0.57) | HRH4 | |
| SCHEMBL4509812 | 0.68 | HRH4 (1.00) | HRH4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | Rigel Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009103032-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |