Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.51 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433512 | 0.80 | CHRNB2 (0.51) | HRH4CHRNB2CHRNA4MAP3K12 | |
| SCHEMBL3430562 | 0.79 | CHRNA7 (0.56) | — | |
| SCHEMBL3432392 | 0.78 | MAP3K12 (0.52) | MAP3K12 | |
| SCHEMBL3430563 | 0.77 | HRH4 (0.54) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL3431228 | 0.75 | CHRNA7 (0.38) | — | |
| SCHEMBL3431233 | 0.72 | HRH4 (0.52) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL603773 | 0.69 | HRH4 (0.54) | HRH4CHRNB2CHRNA4 | |
| SCHEMBL4560009 | 0.69 | HRH4 (0.54) | HRH4 | |
| SCHEMBL603774 | 0.69 | HRH4 (0.54) | HRH4CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL17180365 | 0.69 | CHRNB2 (0.56) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017007658-A1 | A COMBINATION FOR IMMUNE MEDIATED CANCER TREATMENT | RIGEL PHARMACEUTICALS, INC. (US) | 2017-01-12 | — | — | WO | claimed |
| EP-2265607-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | Rigel Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009103032-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |