Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037028 | 0.91 | PREP (0.54) | PREPL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18281710 | 0.87 | PREP (0.45) | PREPFKBP1AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL9037209 | 0.84 | KLK7 (0.51) | PREPFKBP1A | |
| SCHEMBL19349915 | 0.82 | PREP (0.55) | PREPFKBP1AALDH1A1L3MBTL1 | |
| SCHEMBL14535955 | 0.82 | PREP (0.55) | PREPFKBP1AALDH1A1L3MBTL1 | |
| SCHEMBL1122258 | 0.81 | PREP (0.55) | PREPL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1122261 | 0.81 | PREP (0.55) | PREPL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1777431 | 0.81 | USP2 (0.61) | PREPL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1777437 | 0.81 | USP2 (0.61) | PREPL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6360197 | 0.81 | ABHD6 (0.56) | PREPSPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |