Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31380183 | 0.78 | APP (0.36) | HAO1APP | |
| SCHEMBL22353122 | 0.78 | APP (0.59) | HAO1APPKDM4ETP53 | |
| SCHEMBL13597759 | 0.78 | HRH3 (0.41) | GRM5FFAR1HAO1APPACHE | |
| SCHEMBL7717366 | 0.78 | GRM5 (0.50) | GRM5FFAR1HAO1APPKDM4E | |
| SCHEMBL718949 | 0.78 | GRM5 (0.50) | GRM5FFAR1HAO1APPKDM4E | |
| SCHEMBL10300106 | 0.78 | GRM5 (0.50) | GRM5FFAR1HAO1APPKDM4E | |
| SCHEMBL562862 | 0.77 | APP (0.55) | GRM5HAO1APPNR1H2KDM4E | |
| Charcoal, Activated SCHEMBL31286307 | 0.75 | GRM5 (0.48) | GRM5FFAR1HAO1APPKDM4E | |
| Fluoride SCHEMBL31286313 | 0.75 | GRM5 (0.48) | GRM5FFAR1HAO1APPKDM4E | |
| SCHEMBL700507 | 0.75 | HTT (0.46) | GRM5FFAR1HAO1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551834-B1 | SUBSTITUTED QUINAZOLINONE COMPOUNDS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-25 | — | — | EP | claimed |
| CN-114702504-B | Trifluoromethyl substituted indolopyranone compound, preparation method thereof and application thereof in antitumor drugs | 平顶山学院 | 2023-04-07 | — | — | CN | disclosed |
| CN-114702504-A | Trifluoromethyl substituted indolopyranone compound, preparation method thereof and application thereof in antitumor drugs | 平顶山学院 | 2022-07-05 | — | — | CN | disclosed |