Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 12/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433060 | 1.00 | OPRL1 (0.56) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| SCHEMBL3405972 | 0.80 | OPRL1 (0.60) | OPRL1OPRM1KDM4EHTR1AHTR2A | |
| SCHEMBL3405263 | 0.76 | OPRM1 (0.47) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3405264 | 0.76 | OPRM1 (0.47) | OPRL1OPRM1OPRK1 | |
| SCHEMBL5164684 | 0.75 | OPRL1 (0.70) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| SCHEMBL12918432 | 0.75 | OPRL1 (0.70) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL5164066 | 0.74 | OPRL1 (0.69) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| SCHEMBL2378536 | 0.74 | OPRL1 (0.49) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| SCHEMBL5341928 | 0.74 | OPRL1 (0.61) | OPRL1OPRM1KDM4EMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL2382884 | 0.74 | OPRL1 (0.48) | OPRL1OPRM1KDM4EMAPTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083790-B | Spiro (5.5) undecane derivatives | GRUENENTHAL GMBH | 2014-03-05 | — | — | CN | disclosed |
| US-8288430-B2 | Spiro(5.5)undecane derivatives | GRUNENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| EP-2257526-B1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-12-14 | — | — | EP | disclosed |
| CN-102083790-A | Spiro (5.5) undecane derivatives | GRUENENTHAL GMBH | 2011-06-01 | — | — | CN | disclosed |
| EP-2257526-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009118169-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | OPRL1, OPRD1, OPRM1 | OPRL1 1/4885OPRM1 3/4885KDM4E 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.