Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915815 | 0.80 | BCHE (0.47) | PTGER3PTGER2PTGER4SLC6A2SLC6A4 | |
| SCHEMBL5915534 | 0.80 | BCHE (0.47) | PTGER3PTGER2PTGER4SLC6A2SLC6A4 | |
| SCHEMBL5915531 | 0.77 | BCHE (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5915528 | 0.77 | BCHE (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5915588 | 0.77 | BCHE (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL780429 | 0.77 | IAPP (0.47) | IAPPNFE2L2PTGER3PTGER2PTGER4 | |
| SCHEMBL780428 | 0.77 | IAPP (0.47) | IAPPNFE2L2PTGER3PTGER2PTGER4 | |
| SCHEMBL5915789 | 0.77 | MAOB (0.44) | NFE2L2LMNAMAPT | |
| SCHEMBL5915673 | 0.77 | MAOB (0.44) | NFE2L2LMNAMAPT | |
| SCHEMBL5915745 | 0.76 | LMNA (0.53) | SLC6A2SLC6A4SLC6A3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |