Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780429 | 1.00 | IAPP (0.47) | IAPPNFE2L2ALDH1A1KDM4EPTGER3 | |
| SCHEMBL11196141 | 0.78 | ALDH1A1 (0.64) | ALDH1A1KDM4ELMNAMAPTHDAC3 | |
| SCHEMBL11196140 | 0.78 | ALDH1A1 (0.64) | ALDH1A1KDM4ELMNAMAPTHDAC3 | |
| SCHEMBL20124823 | 0.78 | ALOX5 (0.44) | NFE2L2ALDH1A1PTGER3PTGER2PTGER4 | |
| SCHEMBL3433130 | 0.77 | IAPP (0.53) | IAPPNFE2L2PTGER3PTGER2PTGER4 | |
| Hydrochloric Acid SCHEMBL11202359 | 0.76 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTHDAC3 | |
| Hydrochloric Acid SCHEMBL11202356 | 0.76 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTHDAC3 | |
| SCHEMBL309761 | 0.75 | PTGER3 (0.63) | PTGER3PTGER2PTGER4MAPTTBXA2R | |
| SCHEMBL3214322 | 0.75 | PTGER3 (0.63) | PTGER3PTGER2PTGER4MAPTTBXA2R | |
| SCHEMBL1150939 | 0.75 | PTGER3 (0.63) | PTGER3PTGER2PTGER4MAPTTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250041255-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE SKIN DISEASES | YALE UNIVERSITY | 2025-02-06 | — | — | US | disclosed |
| US-10881656-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2021-01-05 | — | — | US | disclosed |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-9604958-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
| US-4400380-A | HERBES VIRUS; TOPICAL | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881656-B2 | HIF inhibitors and use thereof | HIF1AN, HIF1A, EGLN3 | IAPP 1352/4885NFE2L2 11/4885ALDH1A1 595/4885 |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | IAPP 1352/4885NFE2L2 11/4885ALDH1A1 595/4885 |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | IAPP 1352/4885NFE2L2 11/4885ALDH1A1 595/4885 |
| US-20250041255-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE SKIN DISEASES | HIF1AN, HIF1A, SSB | IAPP 1722/4885NFE2L2 467/4885ALDH1A1 4339/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | IAPP 1352/4885NFE2L2 11/4885ALDH1A1 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.