Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TLR2 | O60603 | 3/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617550 | 0.93 | ALDH1A1 (0.47) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL1616928 | 0.86 | NR2E1 (0.46) | ALDH1A1LMNAMAPTCYP3A4TDP1 | |
| SCHEMBL23292585 | 0.82 | TLR2 (0.49) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL1616767 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL3431001 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KMT2ALMNAMAPTTHRB | |
| SCHEMBL8475128 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL8822091 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KMT2ALMNAMAPTTHRB | |
| SCHEMBL8822076 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL20085597 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2ATLR2TLR1LMNA | |
| SCHEMBL8034073 | 0.77 | TLR2 (0.49) | ALDH1A1TLR2TLR1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
| EP-1286998-A1 | OXAZOLIDINONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001081350-A1 | OXAZOLIDINONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ASTRAZENECA AB (SE) | 2001-11-01 | — | — | WO | disclosed |