Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617550 | 0.83 | ALDH1A1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3433157 | 0.77 | ALDH1A1 (0.41) | TLR2TLR1S1PR4 | |
| SCHEMBL23292585 | 0.76 | TLR2 (0.49) | TLR2TLR1S1PR4 | |
| SCHEMBL961555 | 0.74 | ALDH1A1 (0.47) | S1PR4 | |
| SCHEMBL10189854 | 0.74 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1616767 | 0.71 | ALDH1A1 (0.49) | TLR2TLR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8475128 | 0.70 | ALDH1A1 (0.50) | TLR2TLR1 | |
| Nitric Acid SCHEMBL1617375 | 0.69 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nitric Acid SCHEMBL1617372 | 0.69 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nitric Acid SCHEMBL1617470 | 0.69 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |