Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830292 | 0.83 | NPY2R (0.49) | NPY2RCYP2D6MAPK1CYP2C19ALDH1A1 | |
| Indene SCHEMBL7745309 | 0.73 | CYP2D6 (0.50) | CYP2D6PKMCYP2C19ALDH1A1ACHE | |
| SCHEMBL7637220 | 0.72 | GBA1 (0.47) | ALDH1A1CA12CA9CA1CA2 | |
| Benzenesulfonamide SCHEMBL27317322 | 0.71 | CA2 (0.55) | CYP2D6CYP2C19ALDH1A1CA12CA9 | |
| Indene SCHEMBL27370267 | 0.70 | CA1 (0.50) | CYP2D6CYP2C19CA1CA2 | |
| Indene SCHEMBL27563612 | 0.70 | CA1 (0.53) | CYP2D6CYP2C19ACHECA9CA1 | |
| Indene SCHEMBL8971580 | 0.70 | CA1 (0.53) | CYP2D6CYP2C19CA1CA2 | |
| SCHEMBL212443 | 0.69 | KMT2A (0.46) | ALDH1A1GAACA12CA9CA1 | |
| Indene SCHEMBL29142763 | 0.69 | CA1 (0.46) | CYP2D6CYP2C19ALDH1A1ACHECA1 | |
| Indene SCHEMBL27714403 | 0.69 | CA1 (0.46) | CYP2D6CYP2C19CA1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916566-B2 | Pyridazinone compounds as phosphodiesterase inhibitors and methods of treating disorders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-12-23 | — | — | US | disclosed |
| US-20100197651-A1 | Pyridazinone compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197651-A1 | Pyridazinone compounds | PDE3A, PDE5A, PDE3B | NPY2R 900/4885CYP2D6 166/4885MAPK1 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.