Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 8/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | ROS1 | P08922 | 2/20 | 0.38 |
| ▸ | FER | P16591 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216667 | 0.79 | CDK8 (0.50) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL3431534 | 0.75 | CDK8 (0.68) | LRRK2CDK8AXLCDK7PLK4 | |
| SCHEMBL217433 | 0.72 | LRRK2 (0.46) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL27699368 | 0.69 | CDK8 (0.67) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL4831566 | 0.68 | CDK8 (0.66) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL16720139 | 0.67 | ADORA2A (0.42) | CDK8PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12807118 | 0.67 | PIK3CD (0.66) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL4831501 | 0.65 | CDK8 (0.81) | LRRK2CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL3431579 | 0.64 | ALDH1A3 (0.49) | LRRK2PLK4KDRCDK5ALDH1A2 | |
| SCHEMBL4006504 | 0.63 | CYP1A2 (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262804-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009144392-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | WO | disclosed |