Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 3/20 | 0.46 |
| ▸ | PARN | O95453 | 1/20 | 0.45 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776927 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL20969999 | 0.91 | SMN1; SMN2 (0.45) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL23115569 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL3425174 | 0.86 | PDE5A (0.46) | SMN1; SMN2POLBHIF1AALDH1A1KMT2A | |
| SCHEMBL6797064 | 0.86 | GAA (0.43) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL28814905 | 0.85 | GAA (0.59) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL7437138 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL7983821 | 0.84 | PDE4A (0.45) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 | |
| SCHEMBL1573111 | 0.84 | PDE5A (0.51) | GAAPOLBALDH1A1KMT2APDE5A | |
| SCHEMBL5798036 | 0.83 | HPGD (0.47) | SMN1; SMN2GAAPOLBHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799524-B2 | Substrates for O6-alkylguanina-DNA alkyltransferase | Ecole Polytechnique Ferdeale de Lausanne (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL). (CH) | 2006-02-02 | — | — | US | disclosed |
| EP-1546371-A1 | SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031405-A1 | SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | AGT, OGG1, NUDT1 | SMN1; SMN2 4215/4885GAA 1247/4885POLB 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.