Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055898 | 0.98 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| Hydrochloric Acid SCHEMBL3479723 | 0.96 | KDM4E (0.53) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| Bromide SCHEMBL15546500 | 0.96 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| SCHEMBL11004427 | 0.78 | KDM4E (0.46) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| SCHEMBL3087633 | 0.77 | KDM4E (0.44) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| Iodide SCHEMBL9773070 | 0.76 | KDM4E (0.41) | KDM4EHDAC8ACHEBCHE | |
| Iodide SCHEMBL4396612 | 0.76 | HDAC8 (0.48) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| Iodide SCHEMBL9390139 | 0.76 | KDM4E (0.41) | KDM4EHDAC8ACHEBCHEALDH1A1 | |
| SCHEMBL11004432 | 0.75 | KDM4E (0.43) | SMN1; SMN2NPC1RAB9APOLBKDM4E | |
| SCHEMBL8922515 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004202-A1 | Quaternary ammonium-functionalized-POSS compounds | NDSU RESEARCH FOUNDATION | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004202-A1 | Quaternary ammonium-functionalized-POSS compounds | ARG1, SAE1, RBX1 | ACHE 1569/4885SMN1; SMN2 1012/4885NPC1 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.