Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429585 | 0.84 | MAPT (0.68) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL21675567 | 0.82 | TP53 (0.57) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL5597699 | 0.82 | KMT2A (0.90) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL30101230 | 0.82 | KMT2A (0.90) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL12989341 | 0.82 | LMNA (0.71) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL3425967 | 0.81 | SMN1; SMN2 (0.77) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL3868620 | 0.81 | MAPT (0.62) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL11252702 | 0.80 | MAPT (0.52) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL4548162 | 0.80 | KMT2A (0.87) | TP53SMN1; SMN2KDM4EMAPTMEN1 | |
| Benzene SCHEMBL11583640 | 0.80 | SMN1; SMN2 (0.80) | TP53SMN1; SMN2KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012002502-A1 | DIHYDROPYRIMIDINONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 大日本住友製薬株式会社 (JP) | 2012-01-05 | — | — | WO | disclosed |