Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL11583640 | 0.98 | SMN1; SMN2 (0.80) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL18415216 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL5597699 | 0.85 | KMT2A (0.90) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL30101230 | 0.85 | KMT2A (0.90) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL4548162 | 0.84 | KMT2A (0.87) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL2632866 | 0.83 | MAPT (0.73) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL22025444 | 0.82 | KMT2A (0.68) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL5458066 | 0.82 | ALDH1A1 (0.77) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL11583635 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4ETP53HTTMAPT | |
| SCHEMBL22024980 | 0.81 | KMT2A (0.77) | SMN1; SMN2KDM4ETP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220054489-A1 | AURORA KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-02-24 | — | — | US | disclosed |
| US-10870647-B2 | Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) | 2020-12-22 | — | — | US | disclosed |
| US-20190315738-A1 | NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) | 2019-10-17 | — | — | US | disclosed |
| US-20160250211-A1 | AURORA KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| WO-2012002502-A1 | DIHYDROPYRIMIDINONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 大日本住友製薬株式会社 (JP) | 2012-01-05 | — | — | WO | disclosed |
| US-7989422-B2 | Antibacterial agents | ALCHEMIA LIMITED (AU) | 2011-08-02 | — | — | US | disclosed |
| US-20100331305-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| US-20090023669-A1 | Antibacterial Agents | ALCHEMIA LIMITED (AU) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331305-A1 | OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, PIK3CA, RICTOR | SMN1; SMN2 1953/4885KDM4E 2554/4885TP53 432/4885 |
| US-20220054489-A1 | AURORA KINASE INHIBITORS | AURKC, AURKA, AURKB | SMN1; SMN2 4435/4885KDM4E 2244/4885TP53 26/4885 |
| US-20160250211-A1 | AURORA KINASE INHIBITORS | AURKC, AURKA, AURKB | SMN1; SMN2 4435/4885KDM4E 2244/4885TP53 26/4885 |
| US-20190315738-A1 | NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER | FYN, SRC, LCK | SMN1; SMN2 1959/4885KDM4E 1524/4885TP53 232/4885 |
| US-10870647-B2 | Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer | FYN, SRC, LCK | SMN1; SMN2 1996/4885KDM4E 1486/4885TP53 205/4885 |
| US-20090023669-A1 | Antibacterial Agents | MRPL21, FUT6, FUT5 | SMN1; SMN2 4524/4885KDM4E 3876/4885TP53 4844/4885 |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, TYMS, DTYMK | SMN1; SMN2 1868/4885KDM4E 2804/4885TP53 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.