Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478394 | 0.87 | F11 (0.48) | F11NPC1MAPTHPGDRAB9A | |
| SCHEMBL478391 | 0.87 | F11 (0.48) | F11NPC1MAPTHPGDRAB9A | |
| SCHEMBL478811 | 0.76 | F11 (0.58) | F11MAPTHPGDRAB9AF10 | |
| SCHEMBL479154 | 0.76 | F11 (0.51) | F11MAPTHPGDSMN1; SMN2MEN1 | |
| SCHEMBL478714 | 0.71 | ALDH1A1 (0.46) | F11MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL479341 | 0.71 | F11 (0.53) | F11NPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL479338 | 0.71 | F11 (0.53) | F11NPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL478910 | 0.70 | F11 (0.48) | F11NPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL479089 | 0.70 | F11 (0.50) | F11NPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL478460 | 0.69 | F11 (0.47) | F11NPC1RAB9ASMN1; SMN2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |