Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126812 | 0.82 | GSK3A (0.64) | MAPK1DYRK1AGSK3AGSK3BDYRK1B | |
| SCHEMBL7128018 | 0.77 | GSK3A (0.58) | MAPK1GSK3AGSK3BCHEK1FGFR1 | |
| SCHEMBL1496202 | 0.75 | DYRK1A (0.47) | MAPK1DYRK1AGSK3AGSK3BDYRK1B | |
| SCHEMBL12726035 | 0.73 | DYRK1A (0.45) | MAPK1DYRK1AGSK3AGSK3BDYRK1B | |
| SCHEMBL7256652 | 0.72 | BRAF (0.56) | MAPTBRAFMAPK1DYRK1AGSK3A | |
| SCHEMBL19736370 | 0.72 | DYRK1A (0.49) | MAPK1DYRK1AGSK3AGSK3B | |
| SCHEMBL1496236 | 0.71 | CYP1A2 (0.49) | POLBMAPTMAPK1DYRK1AGSK3B | |
| SCHEMBL1592868 | 0.71 | MAPK1 (0.51) | MAPTMAPK1GSK3AGSK3B | |
| SCHEMBL628880 | 0.68 | DYRK1A (0.63) | POLBMAPTMAPK1DYRK1AGSK3A | |
| SCHEMBL29930701 | 0.68 | DYRK1B (0.67) | MAPTBRAFMAPK1DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265610-A1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |