Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930889 | 0.88 | DYRK1B (0.69) | DYRK1BDYRK1AMAPTMAPK1LMNA | |
| SCHEMBL29930670 | 0.87 | DYRK1B (0.70) | DYRK1BDYRK1ANPC1RAB9AGSK3B | |
| SCHEMBL29930851 | 0.87 | DYRK1B (0.73) | DYRK1BDYRK1AMAPTMAPK1LMNA | |
| SCHEMBL29930804 | 0.82 | DYRK1A (0.70) | DYRK1BDYRK1AMAPTMAPK1MEN1 | |
| SCHEMBL29930702 | 0.78 | DYRK1B (0.73) | DYRK1BDYRK1AMAPT | |
| SCHEMBL28562998 | 0.78 | DYRK1B (0.61) | DYRK1BDYRK1AMAPTMAPK1MEN1 | |
| SCHEMBL29930500 | 0.78 | DYRK1A (0.47) | DYRK1BDYRK1AMAPTMAPK1MEN1 | |
| SCHEMBL29930763 | 0.77 | DYRK1B (0.71) | DYRK1BDYRK1AMAPTMEN1NPC1 | |
| SCHEMBL6684639 | 0.74 | LMNA (0.57) | DYRK1BDYRK1AMAPTMAPK1LMNA | |
| SCHEMBL29930898 | 0.73 | DYRK1A (0.65) | DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |