Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661772 | 0.98 | MAPT (0.47) | MAPTTP53GAAMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL29259617 | 0.96 | MAPT (0.46) | MAPTTP53GAAMAPK1HSD17B10 | |
| SCHEMBL17865619 | 0.88 | ALDH1A1 (0.37) | MAPTTP53GAAMAPK1HSD17B10 | |
| SCHEMBL1485712 | 0.82 | MAPT (0.59) | MAPTTP53GAAALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2866031 | 0.81 | MAPT (0.57) | MAPTTP53GAAALDH1A1KMT2A | |
| SCHEMBL15928718 | 0.80 | CYP3A4 (0.45) | MAPTTP53GAAMAPK1HSD17B10 | |
| SCHEMBL9273078 | 0.80 | MAPT (0.45) | MAPTTP53GAAMAPK1HSD17B10 | |
| SCHEMBL6474538 | 0.79 | MAPT (0.47) | MAPTTP53GAAMAPK1HSD17B10 | |
| SCHEMBL11245637 | 0.76 | GAA (0.41) | MAPTTP53GAAALDH1A1KMT2A | |
| SCHEMBL11170519 | 0.76 | MAPT (0.67) | MAPTTP53GAAMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004202-A1 | Quaternary ammonium-functionalized-POSS compounds | NDSU RESEARCH FOUNDATION | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004202-A1 | Quaternary ammonium-functionalized-POSS compounds | ARG1, SAE1, RBX1 | CHRM1 169/4885MAPT 4210/4885TP53 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.