Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 6/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | HRH2 | P25021 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5810193 | 1.00 | SCN4A (0.61) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL5810188 | 1.00 | SCN4A (0.61) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| Bromide SCHEMBL4631988 | 0.99 | SCN4A (0.60) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| Bromide SCHEMBL1234856 | 0.99 | SCN4A (0.60) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL3025573 | 0.87 | SCN4A (0.62) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL8204692 | 0.85 | DRD3 (0.62) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL1031126 | 0.85 | DRD3 (0.62) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL1031127 | 0.85 | DRD3 (0.62) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| SCHEMBL31214169 | 0.84 | SCN4A (0.67) | SCN4ASCN3ASCN9ADRD3DRD2 | |
| Bromide SCHEMBL4103965 | 0.84 | DRD3 (0.61) | SCN4ASCN3ASCN9ADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111018805-A | Synthesis and separation method of pramipexole intermediate | 江苏汉斯通药业有限公司 | 2020-04-17 | — | — | CN | claimed |
| CN-110734413-A | Preparation method of pramipexole intermediates 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole | 山东铂源药业有限公司 | 2020-01-31 | — | — | CN | claimed |
| WO-2008104847-A2 | PROCESSES FOR THE PREPARATION OF PRAMIPEXOLE AND SALTS THEREOF | WOCKHARDT RESEARCH CENTRE (IN) | 2008-09-04 | — | — | WO | claimed |
| EP-1562921-B1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | CIPLA LTD (IN) | 2008-05-21 | — | — | EP | claimed |
| US-7285669-B2 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole | CIPLA LIMITED (IN) | 2007-10-23 | — | — | US | claimed |
| US-20060100256-A1 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole | CIPLA LIMITED (IN) | 2006-05-11 | — | — | US | claimed |
| EP-1562921-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | Cipla Ltd. (IN) | 2005-08-17 | — | — | EP | claimed |
| WO-2004041797-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | CIPLA LTD (IN) | 2004-05-21 | — | — | WO | claimed |
| CN-116178304-B | Synthesis method of pramipexole dihydrochloride | 中国药科大学 | 2024-10-25 | — | — | CN | disclosed |
| CN-116178304-A | Synthesis method of pramipexole dihydrochloride | 中国药科大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-112608286-B | Preparation method of high-purity pramipexole | 广东红珊瑚药业有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-112608286-A | Preparation method of high-purity pramipexole | 广东红珊瑚药业有限公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-111362884-A | Industrial preparation method of 2, 6-diamino-4, 5,6, 7-tetrahydro-benzothiazole | 江苏神龙药业股份有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-111362884-A | Industrial preparation method of 2, 6-diamino-4, 5,6, 7-tetrahydro-benzothiazole | 江苏神龙药业股份有限公司 | 2020-07-03 | — | — | CN | disclosed |
| EP-1562921-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | Cipla Ltd. (IN) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004041797-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | CIPLA LTD (IN) | 2004-05-21 | — | — | WO | disclosed |
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100256-A1 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole | DNPEP, DDO, HNMT | SCN4A 2954/4885SCN3A 4555/4885SCN9A 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.