Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433281 | 0.78 | HPGD (0.50) | KMT2AMEN1ALDH1A1TACR1HPGD | |
| SCHEMBL1362397 | 0.78 | ERN1 (0.47) | KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL2559209 | 0.73 | TRIM24 (0.53) | ALDH1A1TRIM24TRIM33HPGD | |
| SCHEMBL13761135 | 0.72 | MAOA (0.40) | ALDH1A1TRIM24TRIM33HPGD | |
| SCHEMBL2560353 | 0.70 | TRIM24 (0.63) | KMT2AMEN1ALDH1A1TRIM24TRIM33 | |
| SCHEMBL6185510 | 0.68 | AOC3 (0.45) | KMT2AMEN1ALDH1A1AOC3 | |
| SCHEMBL4164586 | 0.67 | KMT2A (0.66) | KMT2AMEN1ALDH1A1HPGDHSP90AA1 | |
| SCHEMBL15332919 | 0.67 | TRIM24 (0.62) | TRIM24TRIM33 | |
| SCHEMBL2558013 | 0.67 | TRIM24 (0.62) | TRIM24TRIM33 | |
| SCHEMBL6715008 | 0.67 | TRIM24 (0.57) | ALDH1A1TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |