Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 4/20 | 0.48 |
| ▸ | TACR2 | P21452 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405757 | 0.89 | ALDH1A1 (0.48) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL4520187 | 0.80 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL4527992 | 0.80 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL16005739 | 0.80 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL3411365 | 0.79 | CTSA (0.42) | KDM4ELMNAKDM4CPTGER4PPARG | |
| SCHEMBL3434892 | 0.77 | TSHR (0.50) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL3404114 | 0.76 | EGLN1 (0.66) | KDM4ETACR3KDM4CPTGER4 | |
| SCHEMBL3435598 | 0.73 | EGLN1 (0.50) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL3410929 | 0.73 | EGLN1 (0.50) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL5211790 | 0.71 | PPARG (0.53) | KDM4EALDH1A1LMNAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |