Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 0.70 |
| ▸ | ERN1 | O75460 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433790 | 0.88 | HPGD (0.61) | HPGDERN1POLBSLC6A7MEN1 | |
| SCHEMBL4527873 | 0.84 | HPGD (0.97) | HPGDPOLBALDH1A1 | |
| SCHEMBL3429690 | 0.83 | HPGD (0.61) | HPGDPDE4BPDE4D | |
| SCHEMBL4532102 | 0.83 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4560090 | 0.83 | HPGD (0.94) | HPGDPOLBALDH1A1 | |
| SCHEMBL4525058 | 0.83 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| Cx516 SCHEMBL194605 | 0.83 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| Cx516 SCHEMBL31660971 | 0.83 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4520505 | 0.81 | HPGD (0.97) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1442309 | 0.81 | HPGD (0.59) | HPGDERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |