Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | SLC6A7 | Q99884 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435828 | 0.88 | HPGD (0.70) | HPGDMAPK1SLC6A7PDE4BPDE4D | |
| SCHEMBL3429690 | 0.85 | HPGD (0.61) | HPGDPDE4BPDE4D | |
| SCHEMBL3435145 | 0.81 | HPGD (0.56) | HPGDPDE4BPDE4DALDH1A1MEN1 | |
| SCHEMBL3433125 | 0.80 | HPGD (0.55) | HPGDPDE4BPDE4D | |
| SCHEMBL3391582 | 0.79 | HPGD (0.54) | HPGDSLC6A7PDE4BPDE4DMEN1 | |
| SCHEMBL4527873 | 0.78 | HPGD (0.97) | HPGDALDH1A1POLB | |
| SCHEMBL24686234 | 0.78 | TGFBR1 (0.50) | ALDH1A1NPC1RAB9APOLBL3MBTL1 | |
| Cx516 SCHEMBL31660971 | 0.77 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| Cx516 SCHEMBL194605 | 0.77 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4525058 | 0.77 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |