Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 14/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433790 | 0.85 | HPGD (0.61) | HPGDPDE4BPDE4D | |
| SCHEMBL3435828 | 0.83 | HPGD (0.70) | HPGDPDE4BPDE4D | |
| SCHEMBL3433125 | 0.82 | HPGD (0.55) | HPGDECE2PDE4BPDE4DCCNT1 | |
| SCHEMBL3435145 | 0.81 | HPGD (0.56) | HPGDKDM4EECE2PDE4BPDE4D | |
| SCHEMBL3391582 | 0.79 | HPGD (0.54) | HPGDECE2PDE4BPDE4D | |
| SCHEMBL4527873 | 0.78 | HPGD (0.97) | HPGDECE2 | |
| SCHEMBL4532102 | 0.77 | HPGD (1.00) | HPGDECE2 | |
| Cx516 SCHEMBL194605 | 0.77 | HPGD (1.00) | HPGDECE2 | |
| SCHEMBL4525058 | 0.77 | HPGD (1.00) | HPGDECE2 | |
| Cx516 SCHEMBL31660971 | 0.77 | HPGD (1.00) | HPGDECE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |