Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436734 | 0.88 | OPRK1 (0.43) | OPRK1MAPTSMN1; SMN2HRH3ACACB | |
| SCHEMBL3555340 | 0.80 | MAPT (0.56) | MAPTSMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL3436536 | 0.79 | MAPT (0.43) | MAPTSMN1; SMN2HRH3ACACBGAA | |
| SCHEMBL3436737 | 0.79 | OPRK1 (0.42) | OPRK1CHRM1HRH3SMOCHRM2 | |
| SCHEMBL3436535 | 0.78 | HRH3 (0.47) | HRH3KMT2A | |
| SCHEMBL10278139 | 0.77 | KDM4E (0.50) | OPRK1CHRM1CYP2C19KDM4EALDH1A1 | |
| SCHEMBL3552005 | 0.76 | OPRK1 (0.43) | OPRK1MAPTSMN1; SMN2CHRM1KDM4E | |
| SCHEMBL3436507 | 0.76 | KDM4E (0.51) | OPRK1SMN1; SMN2CHRM1CYP2C19KDM4E | |
| SCHEMBL3552903 | 0.75 | KMT2A (0.44) | OPRK1MAPTSMN1; SMN2CHRM1MEN1 | |
| SCHEMBL27703257 | 0.73 | OPRK1 (0.45) | OPRK1MAPTSMN1; SMN2HRH3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | OPRK1 237/4885MAPT 1330/4885SMN1; SMN2 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.