Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.65 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.65 |
| ▸ | ABAT | P80404 | 1/20 | 0.65 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.65 |
| ▸ | TYR | P14679 | 2/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.62 |
| ▸ | STAT3 | P40763 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | TTR | P02766 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coniferyl Aldehyde SCHEMBL167835 | 0.93 | XDH (1.00) | XDHALDH1A1HPGDTDP1TRIM24 | |
| Coniferyl Aldehyde SCHEMBL198485 | 0.93 | XDH (1.00) | XDHALDH1A1HPGDTDP1TRIM24 | |
| Coniferyl Aldehyde SCHEMBL29404938 | 0.93 | XDH (1.00) | XDHALDH1A1HPGDTDP1TRIM24 | |
| Coniferyl Aldehyde SCHEMBL13144559 | 0.93 | XDH (1.00) | XDHALDH1A1HPGDTDP1TRIM24 | |
| Coniferyl Aldehyde SCHEMBL30365777 | 0.93 | XDH (1.00) | XDHALDH1A1HPGDTDP1TRIM24 | |
| SCHEMBL21798699 | 0.92 | XDH (0.77) | XDHALDH1A1HPGDTDP1TRIM24 | |
| SCHEMBL1426730 | 0.85 | XDH (0.63) | XDHALDH1A1HPGDNFE2L2CYP1A2 | |
| SCHEMBL4268088 | 0.85 | XDH (0.73) | XDHALDH1A1HPGDTDP1TRIM24 | |
| SCHEMBL1426731 | 0.85 | XDH (0.63) | XDHALDH1A1HPGDNFE2L2CYP1A2 | |
| SCHEMBL4268082 | 0.85 | XDH (0.73) | XDHALDH1A1HPGDTDP1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| EP-1797064-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2009-06-24 | — | — | EP | disclosed |
| EP-1797064-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029515-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | THE HOSPITAL FOR SICK CHILDREN | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | MKI67, CCNA2, CDK4 | XDH 3225/4885ALDH1A1 428/4885HPGD 697/4885 |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | MKI67, CALU, CDK4 | XDH 3720/4885ALDH1A1 1908/4885HPGD 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.