Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4644522 | 0.90 | ALDH1A1 (0.59) | KDM4EMAPTLMNAKMT2AMEN1 | |
| SCHEMBL3829716 | 0.87 | KDM4E (0.59) | KDM4EMAPTMAPK1LMNACYP3A4 | |
| SCHEMBL7029122 | 0.85 | KDM4E (0.48) | KDM4EMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL8350638 | 0.83 | KDM4E (0.47) | KDM4EMAPTMAPK1LMNACYP3A4 | |
| SCHEMBL3437174 | 0.83 | KDM4E (0.47) | KDM4EMAPTMAPK1LMNACYP3A4 | |
| SCHEMBL3437175 | 0.83 | KDM4E (0.47) | KDM4EMAPTMAPK1LMNACYP3A4 | |
| SCHEMBL6703981 | 0.82 | CYP3A4 (0.44) | KDM4EMAPTCYP3A4ALDH1A1RAB9A | |
| SCHEMBL21807289 | 0.82 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1RAB9AGAA | |
| SCHEMBL11464187 | 0.82 | SRC (0.47) | KDM4ELMNASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10774506 | 0.82 | ERN1 (0.66) | KDM4EMAPTLMNACYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013114040-A1 | NOVEL COMPOUNDS AND COMPOSITIONS USED AS ANTICANCER AGENTS | UNIVERSITE PARIS DIDEROT - PARIS 7 (FR) | 2013-08-08 | — | — | WO | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| EP-1797064-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2009-06-24 | — | — | EP | disclosed |
| EP-1797064-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029515-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | THE HOSPITAL FOR SICK CHILDREN | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | MKI67, CCNA2, CDK4 | KDM4E 279/4885MAPT 4694/4885MAPK1 1789/4885 |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | MKI67, CALU, CDK4 | KDM4E 3729/4885MAPT 2662/4885MAPK1 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.