Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3437175 | 1.00 | KDM4E (0.47) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL3437173 | 0.83 | KDM4E (0.53) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL31074934 | 0.83 | CYP1A1 (0.57) | KDM4EKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL344620 | 0.81 | AKR1C3 (0.52) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL344621 | 0.81 | AKR1C3 (0.52) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL9320672 | 0.81 | KDM4E (0.44) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL9320684 | 0.81 | KDM4E (0.44) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL15330637 | 0.80 | CDK4 (0.52) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL6475481 | 0.80 | CDK4 (0.52) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL10412321 | 0.79 | MTNR1A (0.47) | KDM4ELMNAKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| EP-1797064-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2009-06-24 | — | — | EP | disclosed |
| EP-1797064-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029515-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | THE HOSPITAL FOR SICK CHILDREN | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058297-A1 | 4-Chloro-2-cyano-5-phenyl-penta-2E,4Z-dienoic acid 3,4-dihydroxybenzylamide, used as antiproliferative agents | MKI67, CCNA2, CDK4 | KDM4E 279/4885LMNA 1323/4885KMT2A 1519/4885 |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | MKI67, CALU, CDK4 | KDM4E 3729/4885LMNA 2586/4885KMT2A 4561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.