Dihydrokaempferol

Dihydrokaempferol

SCHEMBL3437565

O=C1c2c(O)cc(O)cc2O[C@@H](c2ccc(O)cc2)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.80
MEN1 O00255 4/20 0.80
KMT2A Q03164 4/20 0.80
MAPT P10636 4/20 0.80
HSD17B10 Q99714 4/20 0.80
ALOX15 P16050 4/20 0.80
ALOX12 P18054 3/20 0.80
RECQL P46063 2/20 0.80
SOST Q9BQB4 2/20 0.80
POLB P06746 2/20 0.80
CYP1A2 P05177 2/20 0.80
KDM4E B2RXH2 2/20 0.80
GAA P10253 2/20 0.80
HIF1A Q16665 2/20 0.80
NFKB1 P19838 1/20 0.80
MAPK1 P28482 1/20 0.80
SYNJ2 O15056 1/20 0.74
APP P05067 1/20 0.74
XDH P47989 1/20 0.66
CBS P35520 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dihydrokaempferol SCHEMBL31026899 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL2036629 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL29454736 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL13354175 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL39319 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL29367287 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL3438673 1.00 CYP3A4 (0.80) CYP3A4MEN1KMT2AMAPTHSD17B10
Dihydrokaempferol SCHEMBL31547241 0.93 MAPT (0.70) CYP3A4MEN1KMT2AMAPTHSD17B10
Pinobaksin SCHEMBL14461145 0.91 MAPT (0.75) CYP3A4MEN1KMT2AMAPTHSD17B10
Pinobaksin SCHEMBL1045054 0.91 MAPT (0.75) CYP3A4MEN1KMT2AMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2484773-A2 Process for producing anthocyanins The Research Foundation of State University of New York (US) 2012-08-08 EP disclosed
US-7807422-B2 set of genes which encodes for enzymes which can convert substrates belonging to the general category of phenylpropanoids and result in the production of flavanones; without the need for chemical conversion THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2010-10-05 US disclosed
US-20090239272-A1 set of genes which encodes for enzymes which can convert substrates belonging to the general category of phenylpropanoids and result in the production of flavanones; without the need for chemical conversion KOFFAS MATTHEOS 2009-09-24 US disclosed
US-7338791-B2 Introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes; culturing the cell under conditions permitting the synthesis of the flavonoid by the cells; isolating s flavonoids THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2008-03-04 US disclosed
EP-1778850-A2 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2007-05-02 EP disclosed
US-20060019334-A1 Introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes; culturing the cell under conditions permitting the synthesis of the flavonoid by the cells; isolating s flavonoids NATIONAL SCIENCE FOUNDATION 2006-01-26 US disclosed
WO-2006010117-A2 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2006-01-26 WO disclosed