Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.54 |
| ▸ | CCND1 | P24385 | 6/20 | 0.54 |
| ▸ | CCND2 | P30279 | 5/20 | 0.54 |
| ▸ | CCND3 | P30281 | 5/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.50 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.49 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.49 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167377 | 0.87 | BRD4 (0.49) | CDK4CCND1CCND2CCND3BRD4 | |
| SCHEMBL341737 | 0.87 | EGFR (0.65) | CDK4CCND1CCND2CCND3BRD4 | |
| SCHEMBL343786 | 0.84 | CDK4 (0.54) | CDK4CCND1CCND2CCND3BRD4 | |
| SCHEMBL344178 | 0.81 | CDK4 (0.71) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL12639344 | 0.81 | CDK4 (0.69) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL1355734 | 0.81 | CDK4 (0.69) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL343214 | 0.81 | CDK4 (0.59) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL1355087 | 0.80 | CDK4 (0.73) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL344014 | 0.80 | CDK4 (0.73) | CDK4CCND1CCND2CCND3EGFR | |
| SCHEMBL343351 | 0.80 | CDK1 (0.44) | CDK4CCND1CCND2CCND3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | claimed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | claimed |
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | CDK4 71/4885CCND1 272/4885CCND2 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.