Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.59 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13147969 | 0.87 | HIF1A (0.62) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL2077874 | 0.87 | HIF1A (0.62) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL2077302 | 0.87 | HIF1A (0.62) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685723 | 0.87 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL25854534 | 0.87 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685722 | 0.87 | HIF1A (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL1685716 | 0.79 | PGR (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL7203304 | 0.79 | HIF1A (0.76) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL5098424 | 0.79 | PGR (0.77) | HIF1APGRLMNASERPINA6AR | |
| SCHEMBL7203303 | 0.79 | HIF1A (0.76) | HIF1APGRLMNASERPINA6AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178726-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-07-12 | — | — | US | disclosed |
| US-20120178726-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-07-12 | — | — | US | disclosed |
| US-8163724-B2 | Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-8163724-B2 | Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-20090286835-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
| US-20090286835-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
| WO-2009044200-A1 | STEROIDAL [3, 2-C] PYRAZOLE COMPOUNDS, WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178726-A1 | NOVEL COMPOUNDS | F12, C1R, CXCR4 | HIF1A 2414/4885PGR 161/4885LMNA 1363/4885 |
| US-20090286835-A1 | NOVEL COMPOUNDS | F12, C1R, CXCR4 | HIF1A 2414/4885PGR 161/4885LMNA 1363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.