Glypinamide

Glypinamide

SCHEMBL343885

O=C(NN1CCCCCC1)NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.74
CYP3A4 P08684 2/20 0.74
NFKB1 P19838 2/20 0.74
GAA P10253 2/20 0.74
KDM4E B2RXH2 1/20 0.74
TP53 P04637 1/20 0.74
GLA P06280 1/20 0.74
MAPT P10636 1/20 0.74
ALOX12 P18054 1/20 0.74
LIPE Q05469 2/20 0.52
FLT1 P17948 4/20 0.51
FLT4 P35916 4/20 0.51
KDR P35968 4/20 0.51
TSHR P16473 2/20 0.51
LMNA P02545 2/20 0.51
CYP2C19 P33261 2/20 0.51
THRB P10828 1/20 0.51
HTR2A P28223 1/20 0.51
ADRA1A P35348 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glyclopyramide SCHEMBL49354 0.98 ALDH1A1 (0.71) ALDH1A1CYP3A4NFKB1GAAKDM4E
Glyclopyramide SCHEMBL15669226 0.98 ALDH1A1 (0.71) ALDH1A1CYP3A4NFKB1GAAKDM4E
Tolazamide SCHEMBL34417 0.85 ALDH1A1 (1.00) ALDH1A1CYP3A4NFKB1GAAKDM4E
Tolazamide SCHEMBL13725632 0.85 ALDH1A1 (1.00) ALDH1A1CYP3A4NFKB1GAAKDM4E
Tolazamide SCHEMBL2534564 0.84 ALDH1A1 (0.70) ALDH1A1CYP3A4NFKB1GAAKDM4E
Tolazamide SCHEMBL28562527 0.84 ALDH1A1 (0.97) ALDH1A1CYP3A4NFKB1GAAKDM4E
SCHEMBL11627200 0.83 MCHR1 (0.59) ALDH1A1CYP3A4NFKB1GAAKDM4E
SCHEMBL11626350 0.83 MCHR1 (0.59) ALDH1A1CYP3A4NFKB1GAAKDM4E
Glypinamide SCHEMBL5243890 0.82 ALDH1A1 (0.59) ALDH1A1CYP3A4NFKB1GAAKDM4E
Acetohexamide SCHEMBL20267964 0.82 ALDH1A1 (0.73) ALDH1A1CYP3A4NFKB1GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1820 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12208071-B2 Glucagon receptor antagonists LIGAND PHARMACEUTICALS INCORPORATED (US) 2025-01-28 US claimed
US-20210121422-A1 GLUCAGON RECEPTOR ANTAGONISTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2021-04-29 US claimed
EP-3752249-A1 GLUCAGON RECEPTOR ANTAGONISTS Ligand Pharmaceuticals, Inc. (US) 2020-12-23 EP claimed
WO-2019160940-A1 GLUCAGON RECEPTOR ANTAGONISTS LIGAND PHARMACEUTICALS INCORPORATED (US) 2019-08-22 WO claimed
US-20190194143-A1 GLUCAGON RECEPTOR ANTAGONISTS LIGAND PHARM INC (US) 2019-06-27 US claimed
EP-3500565-A1 GLUCAGON RECEPTOR ANTAGONISTS Ligand Pharmaceuticals, Inc. (US) 2019-06-26 EP claimed
WO-2018035172-A1 GLUCAGON RECEPTOR ANTAGONISTS LIGAND PHARMACEUTICALS, INC. (US) 2018-02-22 WO claimed
US-9359339-B2 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use MERCK SHARP & DOHME CORP. (US) 2016-06-07 US claimed
EP-2346830-B1 GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK SHARP & DOHME (US) 2015-05-13 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2002015892-A2 COMBINATION COMPRISING AN INSULIN SECRETION ENHANCER AND AN ACTIVE INGREDIENT SELECTED FROM HMG-CO-A REDUCTASE INHIBITORS AND ACE INHIBITORS NOVARTIS AG (CH) 2002-02-28 WO claimed
US-6329404-B1 Pharmaceutical composition TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-12-11 US claimed
US-6303640-B1 ADMINISTERING OXAZOLE OR THIAZOLE DERIVATIVE COMPOUND FOR REDUCING SIDE EFFECTS OF DIABETIC THERAPY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-10-16 US claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
US-6211205-B1 ANTIDIABETIC AGENTS THAT ENHANCE INSULIN SECRETION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
US-6150383-A COMPRISING AN INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH ONE OR MORE OTHER ANTIDIABETICS DIFFERING FROM THE ENHANCER IN MECHANISM OF ACTION; LIPID/GLYCOMETABOLISM DISORDERS; ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-11-21 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-5656286-A BLEND OF TWO POLYMERS; PRESSURE SENSITIVE ADHESIVE NOVEN PHARMACEUTICALS, INC. (US) 1997-08-12 US claimed
US-4346709-A Drug delivery devices comprising erodible polymer and erosion rate modifier ALZA CORPORATION (US) 1982-08-31 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121422-A1 GLUCAGON RECEPTOR ANTAGONISTS GLP1R, GCGR, GCG ALDH1A1 4216/4885CYP3A4 1256/4885NFKB1 3537/4885
US-12208071-B2 Glucagon receptor antagonists GLP1R, GCGR, GCG ALDH1A1 4216/4885CYP3A4 1256/4885NFKB1 3537/4885
US-20190194143-A1 GLUCAGON RECEPTOR ANTAGONISTS GLP1R, GCGR, GCG ALDH1A1 4284/4885CYP3A4 1204/4885NFKB1 3317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.