Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tolazamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolazamide SCHEMBL34417 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Tolazamide SCHEMBL28562527 | 0.98 | ALDH1A1 (0.97) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Gliclazide SCHEMBL6344915 | 0.89 | ALDH1A1 (0.88) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Tolazamide SCHEMBL27794828 | 0.88 | ALDH1A1 (0.77) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Tolazamide SCHEMBL992662 | 0.87 | ALDH1A1 (0.75) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Glypinamide SCHEMBL343885 | 0.85 | ALDH1A1 (0.74) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Tolazamide SCHEMBL2534564 | 0.84 | ALDH1A1 (0.70) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Glyclopyramide SCHEMBL49354 | 0.83 | ALDH1A1 (0.71) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Glyclopyramide SCHEMBL15669226 | 0.83 | ALDH1A1 (0.71) | ALDH1A1TP53KDM4EGLACYP3A4 | |
| Tolazamide SCHEMBL747962 | 0.80 | ALDH1A1 (0.65) | ALDH1A1TP53KDM4EGLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| EP-3062782-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-2914252-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2015-09-09 | — | — | EP | disclosed |
| WO-2015063140-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2015-05-07 | — | — | WO | disclosed |
| WO-2014068007-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2014-05-08 | — | — | WO | disclosed |
| WO-2012151309-A1 | METHODS FOR REGULATING INDUCED PLURIPOTENT STEM CELL GENERATION AND COMPOSITIONS THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-11-08 | — | — | WO | disclosed |