Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 15/20 | 0.83 |
| ▸ | PRSS2 | P07478 | 15/20 | 0.83 |
| ▸ | PRSS3 | P35030 | 15/20 | 0.83 |
| ▸ | MAOA | P21397 | 1/20 | 0.83 |
| ▸ | MAOB | P27338 | 1/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3438811 | 0.91 | PRSS1 (0.81) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2110650 | 0.91 | PRSS1 (1.00) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL15255516 | 0.90 | PRSS1 (0.79) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL10254052 | 0.90 | PRSS1 (0.79) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109231 | 0.89 | PRSS1 (0.87) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109847 | 0.87 | PRSS1 (0.77) | PRSS1PRSS2PRSS3MAOAMAOB | |
| Benzoic Acid SCHEMBL2921087 | 0.87 | PRSS1 (0.92) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2108898 | 0.86 | PRSS1 (0.76) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3438812 | 0.86 | PRSS1 (0.77) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3438855 | 0.85 | PRSS1 (0.83) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158792-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | disclosed |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | TPSAB1, TPSB2, TPSD1 | PRSS1 7/4885PRSS2 33/4885PRSS3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.