SCHEMBL3440643

SCHEMBL3440643

CCCCNCC(O)COc1ccc(C(=O)/C=C/c2ccc(OC)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.60
MAPT P10636 4/20 0.56
NPC1 O15118 1/20 0.56
LMNA P02545 1/20 0.56
F3 P13726 2/20 0.55
ABCG2 Q9UNQ0 2/20 0.55
MAOA P21397 3/20 0.51
ALDH1A1 P00352 3/20 0.51
XDH P47989 2/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
P4HB P07237 1/20 0.51
CALM1 P0DP23 1/20 0.51
RAB9A P51151 1/20 0.51
ADRB2 P07550 2/20 0.51
ADRB1 P08588 2/20 0.51
ADRB3 P13945 2/20 0.51
HSPD1 P10809 1/20 0.49
TNFRSF1A P19438 1/20 0.49
HSPE1 P61604 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3440645 1.00 MAOB (0.60) MAOBMAPTNPC1LMNAF3
SCHEMBL3440695 0.86 MAOB (0.60) MAOBMAPTNPC1LMNAF3
SCHEMBL3440696 0.86 MAOB (0.60) MAOBMAPTNPC1LMNAF3
SCHEMBL3440509 0.85 MAOB (0.64) MAOBMAPTNPC1LMNAF3
SCHEMBL3440508 0.85 MAOB (0.64) MAOBMAPTNPC1LMNAF3
SCHEMBL3440702 0.84 ABCB1 (0.51) MAOBMAPTNPC1LMNAABCG2
SCHEMBL3440703 0.84 ABCB1 (0.51) MAOBMAPTNPC1LMNAABCG2
SCHEMBL30383779 0.84 ABCB1 (0.51) MAOBMAPTNPC1LMNAABCG2
SCHEMBL25208761 0.84 MAOB (0.72) MAOBMAPTNPC1LMNAF3
SCHEMBL25193709 0.84 MAOB (0.72) MAOBMAPTNPC1LMNAF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US claimed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US claimed
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US disclosed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885MAPT 3297/4885NPC1 1378/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAPT 3512/4885NPC1 1908/4885
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents LIPC, CYP46A1, HMGCR MAOB 2303/4885MAPT 4801/4885NPC1 110/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885MAPT 3512/4885NPC1 1908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.