Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12639963 | 0.87 | TSHR (0.50) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL502945 | 0.84 | TSHR (0.47) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL2079917 | 0.84 | TSHR (0.47) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL502944 | 0.84 | TSHR (0.47) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL11801659 | 0.81 | TSHR (0.52) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL12930708 | 0.81 | TSHR (0.44) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL11498434 | 0.80 | TSHR (0.47) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL12961615 | 0.76 | TSHR (0.47) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL8959927 | 0.76 | TSHR (0.55) | TSHRCNR2MAPTALDH1A1PSMD14 | |
| SCHEMBL18657302 | 0.76 | TSHR (0.59) | TSHRCNR2MAPTALDH1A1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812047-B2 | 4-imidazolines | HOFFMAN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20090012138-A1 | 4-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012138-A1 | 4-IMIDAZOLINES | TAAR1, TAAR5, GPR119 | TSHR 23/4885CNR2 146/4885MAPT 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.