Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442561 | 0.91 | KMT2A (0.46) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL3442371 | 0.85 | MEN1 (0.47) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL4290464 | 0.84 | NAMPT (0.48) | ALDH1A1LMNAMEN1KMT2ACYP2C9 | |
| SCHEMBL3442175 | 0.81 | MEN1 (0.44) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL2333396 | 0.81 | CHRNB2 (0.46) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL3441493 | 0.80 | ALDH1A1 (0.45) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL3442414 | 0.79 | MEN1 (0.42) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3441676 | 0.79 | ALDH1A1 (0.75) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL3442119 | 0.78 | MEN1 (0.41) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL4301319 | 0.76 | NAMPT (0.47) | CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262792-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009124733-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |