Roxifiban

Roxifiban

SCHEMBL344302

CCCCOC(=O)N[C@@H](CNC(=O)C[C@H]1CC(c2ccc(C(=N)N)cc2)=NO1)C(=O)OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 1.00
ITGA2B P08514 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Roxifiban SCHEMBL24336949 1.00 ITGB3 (1.00) ITGB3ITGA2B
Roxifiban SCHEMBL919675 0.98 ITGB3 (0.95) ITGB3ITGA2B
SCHEMBL7213400 0.94 ITGB3 (1.00) ITGB3ITGA2B
Roxifiban SCHEMBL50632 0.93 ITGB3 (0.86) ITGB3ITGA2B
SCHEMBL7220986 0.91 ITGB3 (0.83) ITGB3ITGA2B
SCHEMBL7407564 0.89 ITGB3 (0.80) ITGB3ITGA2B
SCHEMBL7413714 0.89 ITGB3 (0.80) ITGB3ITGA2B
SCHEMBL7214664 0.86 ITGB3 (0.76) ITGB3ITGA2B
SCHEMBL7217243 0.86 ITGB3 (0.76) ITGB3ITGA2B
SCHEMBL7214752 0.86 ITGB3 (0.76) ITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 954 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12521258-B2 Anticoagulant compounds and methods and devices for their use ELIXIR MEDICAL CORPORATION (US) 2026-01-13 US claimed
US-20250110111-A1 DISPOSABLE SYSTEM FOR ANALYSIS OF HEMOSTATIC FUNCTION HEMOSONICS, LLC 2025-04-03 US claimed
EP-4481381-A2 DISPOSABLE SYSTEM FOR ANALYSIS OF HEMOSTATIC FUNCTION Hemosonics, LLC (US) 2024-12-25 EP claimed
EP-4439040-A2 HEPARIN-BASED BLOOD SAMPLER WITHOUT PLATELET ACTIVATION Radiometer Medical ApS (DK) 2024-10-02 EP claimed
CN-109414452-B Cyclodextrins as procoagulants 阿弗隆制药有限公司 2024-02-02 CN claimed
EP-3154343-B1 RODENT BAIT CONTAINING TWO OR MORE ANTICOAGULATING COMPOUNDS GULBA DIETRICH (DE) 2023-10-25 EP claimed
US-20230227909-A1 METHODS OF DETERMINING THE ETIOLOGY OF ACUTE ISCHEMIC STROKES INSERM INSTITUT NATIONAL DE A SANTE ET DE LA RECH MEDICALE (FR) 2023-07-20 US claimed
US-20230190499-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2023-06-22 US claimed
EP-4158656-A1 METHODS OF DETERMINING THE ETIOLOGY OF ACUTE ISCHEMIC STROKES Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2023-04-05 EP claimed
US-20230058634-A1 PREVENTION OF PLATELET ACTIVATION AND CELL DIFFERENTIATION DURING THE PROCESSING OF BLOOD AND BLOOD-RELATED COMPOSITIONS ZEON CORPORATION (JP) 2023-02-23 US claimed
EP-1189663-A2 SYNERGY BETWEEN LOW MOLECULAR WEIGHT HEPARIN AND PLATELET AGGREGATION INHIBITORS, FOR PREVENTING AND TREATING THROMBOEMBOLIC DISORDERS Du Pont Pharmaceuticals Company (US) 2002-03-27 EP claimed
US-20020032149-A1 Monitoring blood flow parameter of bloodstream, administering substance to organism such that an amount of substance enters bloodstream; distributing portion of amount ofsubstance target within organism RHEOLOGICS, INC. 2002-03-14 US claimed
US-6346517-B1 ADMINISTERING TINZAPARIN AND ROXIFIBAN BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-02-12 US claimed
US-20010044584-A1 In vivo delivery methods and compositions RHEOLOGICS, INC. 2001-11-22 US claimed
EP-1061908-A1 COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY ISCHEMIC SYNDROME AND RELATED CONDITIONS Merck & Co., Inc. (US) 2000-12-27 EP claimed
WO-2000053168-A2 SYNERGY BETWEEN LOW MOLECULAR WEIGHT HEPARIN AND PLATELET AGGREGATION INHIBITORS, FOR PREVENTING AND TREATING THROMBOEMBOLIC DISORDERS DU PONT PHARMACEUTICALS COMPANY (US) 2000-09-14 WO claimed
CN-1259940-A Crystalline roxifiban DU PONT MERCK PHARMA (US) 2000-07-12 CN claimed
EP-0991630-A1 CRYSTALLINE ROXIFIBAN THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 2000-04-12 EP claimed
WO-1999045913-A1 COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY ISCHEMIC SYNDROME AND RELATED CONDITIONS MERCK & CO., INC. (US) 1999-09-16 WO claimed
WO-1998057939-A1 CRYSTALLINE ROXIFIBAN THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-23 WO claimed