Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443455 | 0.87 | CNR1 (0.52) | SMN1; SMN2CNR1ROCK2KDRKMT2A | |
| SCHEMBL3442732 | 0.86 | KDR (0.57) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2236715 | 0.85 | MAPT (0.56) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3443775 | 0.85 | KDR (0.50) | TP53MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1702802 | 0.84 | KDR (0.57) | TP53TSHRALDH1A1MAPTNPC1 | |
| SCHEMBL1703259 | 0.82 | KDR (0.57) | MAPTRAB9AROCK2LIMK1HTT | |
| SCHEMBL1704022 | 0.81 | KDR (0.53) | CNR1ROCK2LIMK1KDRKMT2A | |
| SCHEMBL12346315 | 0.81 | ALDH1A1 (0.47) | TSHRALDH1A1MAPTHTTLMNA | |
| SCHEMBL3442309 | 0.80 | MEN1 (0.57) | TP53MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3442391 | 0.80 | KDR (0.56) | MAPTNPC1RAB9ASMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812166-B2 | Kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1807424-A2 | NOVEL KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060178378-A1 | Novel kinase inhibitors | ABBVIE INC. | 2006-08-10 | — | — | US | disclosed |
| WO-2006050109-A2 | NOVEL KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178378-A1 | Novel kinase inhibitors | ABL1, MAP3K19, MAP3K20 | TP53 581/4885TSHR 3327/4885ALDH1A1 3754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.