Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | FLT1 | P17948 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
| ▸ | FLT4 | P35916 | 3/20 | 0.51 |
| ▸ | BLK | P51451 | 3/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443775 | 0.87 | KDR (0.50) | KDRMEN1MAPTRAB9AKMT2A | |
| SCHEMBL3442732 | 0.86 | KDR (0.57) | KDRMEN1MAPTHTTRAB9A | |
| SCHEMBL1702846 | 0.85 | RIPK1 (0.54) | KDRRIPK1KITFLT3FLT1 | |
| SCHEMBL3443455 | 0.85 | CNR1 (0.52) | KDRKMT2AKITFLT3FLT1 | |
| SCHEMBL3443115 | 0.84 | KDR (0.53) | KDRRIPK1KITFLT3FLT1 | |
| SCHEMBL1703159 | 0.84 | KDR (0.60) | KDRRIPK1MEN1MAPTHTT | |
| SCHEMBL3442309 | 0.82 | MEN1 (0.57) | KDRMEN1MAPTHTTRAB9A | |
| SCHEMBL3443290 | 0.82 | TP53 (0.54) | KDRMEN1MAPTHTTRAB9A | |
| SCHEMBL1703240 | 0.81 | KDR (0.45) | KDRRIPK1MEN1MAPTHTT | |
| SCHEMBL3442391 | 0.80 | KDR (0.56) | KDRMEN1MAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807424-B1 | NOVEL KINASE INHIBITORS | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | disclosed |
| US-7812166-B2 | Kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060178378-A1 | Novel kinase inhibitors | ABBVIE INC. | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178378-A1 | Novel kinase inhibitors | ABL1, MAP3K19, MAP3K20 | KDR 434/4885RIPK1 527/4885MEN1 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.