Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656029 | 0.86 | CTNNB1 (0.42) | RAB9ANPC1KMT2A | |
| SCHEMBL1008787 | 0.82 | PTGDR2 (0.55) | RAB9ANPC1CASP3SENP7DEGS1 | |
| SCHEMBL27656110 | 0.81 | NR1H4 (0.47) | RAB9ANPC1CASP3SENP7DEGS1 | |
| SCHEMBL1010884 | 0.70 | PTGDR2 (0.52) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL1010339 | 0.69 | NR1H4 (0.48) | RAB9ANPC1CASP3SENP7DEGS1 | |
| SCHEMBL1008918 | 0.68 | PTGDR2 (0.46) | RAB9APTGDR2 | |
| SCHEMBL1010589 | 0.68 | PTGDR2 (0.50) | MAPTPTGDR2 | |
| SCHEMBL1011048 | 0.67 | SMN1; SMN2 (0.48) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL4330052 | 0.67 | RAB9A (0.78) | RAB9ANPC1CASP3SENP7DEGS1 | |
| SCHEMBL6017027 | 0.67 | TBXA2R (0.48) | RAB9ANPC1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101914065-A | Help to treat pyrimidine derivatives by the disease of CRTH2 mediation | ACTIMIS PHARMACEUTICALS INC | 2010-12-15 | — | — | CN | claimed |
| US-7812160-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | claimed |
| CN-1809539-A | Pyrimidine derivatives useful in the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-07-26 | — | — | CN | claimed |
| CN-101914065-A | Help to treat pyrimidine derivatives by the disease of CRTH2 mediation | ACTIMIS PHARMACEUTICALS INC | 2010-12-15 | — | — | CN | disclosed |
| CN-1809539-A | Pyrimidine derivatives useful in the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-07-26 | — | — | CN | disclosed |