Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BCDIN3D | Q7Z5W3 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445484 | 0.89 | KDM4E (0.49) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 | |
| SCHEMBL3445948 | 0.89 | FLT3 (0.51) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 | |
| SCHEMBL3445051 | 0.89 | FLT3 (0.52) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 | |
| SCHEMBL3445942 | 0.88 | CDK1 (0.52) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3444226 | 0.87 | BCDIN3D (0.47) | BCDIN3DCCNE2CCNA2CCNE1CDK2 | |
| SCHEMBL3445762 | 0.86 | CDK2 (0.56) | KMT2ABCDIN3DKDM4EALDH1A1CCNE2 | |
| SCHEMBL3446162 | 0.86 | CCNE2 (0.46) | MEN1KMT2ABCDIN3DCCNE2CCNA2 | |
| SCHEMBL3446013 | 0.83 | BCDIN3D (0.41) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 | |
| SCHEMBL3444649 | 0.83 | CDK5 (0.40) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 | |
| SCHEMBL3444530 | 0.83 | CLK1 (0.44) | MEN1KMT2ABCDIN3DKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |