Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | BCDIN3D | Q7Z5W3 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445948 | 0.90 | FLT3 (0.51) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3444309 | 0.90 | FLT3 (0.58) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3445162 | 0.89 | MEN1 (0.50) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3445942 | 0.88 | CDK1 (0.52) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3445615 | 0.87 | BCDIN3D (0.52) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3446013 | 0.87 | BCDIN3D (0.41) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3444649 | 0.87 | CDK5 (0.40) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3444530 | 0.87 | CLK1 (0.44) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3445125 | 0.86 | FLT3 (0.47) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3445753 | 0.83 | CDK5 (0.49) | KDM4EMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |