SCHEMBL3445756

SCHEMBL3445756

Fc1ccc(-c2ccccn2)c(F)c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.42
LMNA P02545 3/20 0.42
CCR1 P32246 3/20 0.42
CCR5 P51681 3/20 0.42
CCR8 P51685 3/20 0.42
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.42
METAP1 P53582 1/20 0.42
BLM P54132 1/20 0.42
HIF1A Q16665 1/20 0.42
DOHH Q9BU89 1/20 0.42
P4HTM Q9NXG6 1/20 0.42
PDK2 Q15119 1/20 0.38
RAB9A P51151 4/20 0.37
TP53 P04637 3/20 0.37
HTT P42858 3/20 0.37
L3MBTL1 Q9Y468 3/20 0.37
NPC1 O15118 3/20 0.37
ALDH1A1 P00352 3/20 0.37
TDP1 Q9NUW8 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29986376 0.85 FFAR1 (0.41) KDM4ELMNACCR1CCR5CCR8
SCHEMBL28004077 0.81 MPL (0.35) KDM4ECYP1A2HIF1AL3MBTL1ALDH1A1
SCHEMBL1356335 0.80 KDM4E (0.50) KDM4ELMNACCR1CCR5CCR8
SCHEMBL29901541 0.80 KDM4E (0.50) KDM4ELMNACCR1CCR5CCR8
SCHEMBL27973821 0.77 NPY5R (0.34) KDM4ELMNACCR1CCR5CCR8
SCHEMBL503377 0.76 CCR1 (0.47) KDM4ECCR1CCR5CCR8P2RX7
SCHEMBL28650048 0.76 KDM4E (0.45) KDM4ELMNACCR1CCR5CCR8
SCHEMBL12828418 0.76 KDM4E (0.45) KDM4ELMNACCR1CCR5CCR8
SCHEMBL1358182 0.74 CES1 (0.42) KDM4ELMNACCR1CCR5CCR8
SCHEMBL1356378 0.74 PDK2 (0.37) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190157574-A1 Phosphorescence Device Containing Heterocyclic Phosphate Metal Complexes AAC Technologies Pte. Ltd. (SG) 2019-05-23 US disclosed
CN-104419408-A Organic blue light electrophosphorescent material, preparation method thereof and organic electroluminescent device OCEANS KING LIGHTING SCIENCE 2015-03-18 CN disclosed
US-7915414-B2 Blue-emitting organometallic complexes and their application Chi, Yun (TW) 2011-03-29 US disclosed
US-7816016-B1 hexacoordinated Indium complex made of ligand 1,1-bis(trifluoromethyl)-2-(diphenylphosphino)-ethanol and bis-cyclometallated Ir 2-(2,4-difluoro-3-perfluoroisopropyl-phenyl)-4-carbazolyl-pyridine E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-10-19 US disclosed
US-7816016-B1 hexacoordinated Indium complex made of ligand 1,1-bis(trifluoromethyl)-2-(diphenylphosphino)-ethanol and bis-cyclometallated Ir 2-(2,4-difluoro-3-perfluoroisopropyl-phenyl)-4-carbazolyl-pyridine E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-10-19 US disclosed
US-7816016-B1 hexacoordinated Indium complex made of ligand 1,1-bis(trifluoromethyl)-2-(diphenylphosphino)-ethanol and bis-cyclometallated Ir 2-(2,4-difluoro-3-perfluoroisopropyl-phenyl)-4-carbazolyl-pyridine E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-10-19 US disclosed
US-7476452-B2 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-01-13 US disclosed
US-7476452-B2 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-01-13 US disclosed
US-7476452-B2 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-01-13 US disclosed
US-20080125591-A1 Blue-Emitting Organometallic Complexes And Their Application Chi, Yun (TW) 2008-05-29 US disclosed
US-7320833-B2 Electroluminescent platinum compounds and devices made with such compounds E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-01-22 US disclosed
US-7320833-B2 Electroluminescent platinum compounds and devices made with such compounds E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-01-22 US disclosed
US-7320833-B2 Electroluminescent platinum compounds and devices made with such compounds E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-01-22 US disclosed
US-20070292713-A9 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds LG CHEM, LTD. (KR) 2007-12-20 US disclosed
US-20070292713-A9 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds LG CHEM, LTD. (KR) 2007-12-20 US disclosed
US-20070292713-A9 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds LG CHEM, LTD. (KR) 2007-12-20 US disclosed
WO-2005075597-A2 ELECTROLUMINESCENT IRIDIUM COMPOUNDS WITH FLUORINATED PHENYLPYRIDINE LIGANDS, AND DEVICES MADE WITH SUCH COMPOUNDS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-08-18 WO disclosed
WO-2005075601-A1 ELECTROLUMINESCENT PLATINUM COMPOUNDS AND DEVICES MADE WITH SUCH COMPOUNDS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-08-18 WO disclosed
US-20050037233-A1 Electroluminescent iridium compounds with fluorinated phenylpyridine ligands, and devices made with such compounds E.I. DU PONT DE NEMOURS AND COMPANY 2005-02-17 US disclosed
US-20040197602-A1 Electroluminescent platinum compounds and devices made with such compounds E. I. DU PONT DE NEMOURS AND COMPANY 2004-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125591-A1 Blue-Emitting Organometallic Complexes And Their Application CYBA, IK, CRY1 KDM4E 1230/4885LMNA 2679/4885CCR1 4516/4885
US-20190157574-A1 Phosphorescence Device Containing Heterocyclic Phosphate Metal Complexes TRPC1, TRPC4, TRPC7 KDM4E 4253/4885LMNA 1252/4885CCR1 2731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.