SCHEMBL34464796

SCHEMBL34464796

COC(=O)c1ccc(-c2ccnc(Nc3ccc(C(=O)N4CCN(C)CC4)c(F)c3)n2)cc1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 13/20 0.50
▸ JAK2 O60674 3/20 0.49
▸ CAMK2D Q13557 1/20 0.49
▸ CDK2 P24941 2/20 0.48
▸ CDK1 P06493 1/20 0.48
▸ CCNA2 P20248 1/20 0.48
▸ CCNA1 P78396 1/20 0.48
▸ JAK3 P52333 2/20 0.47
▸ ABL1 P00519 1/20 0.46
▸ BCR P11274 1/20 0.46
▸ SRC P12931 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34464867 0.91 CAMK2D (0.53) SYKJAK2CAMK2DCDK2CDK1
SCHEMBL34464745 0.90 JAK2 (0.56) SYKJAK2CAMK2DCDK2JAK3
SCHEMBL34464820 0.90 JAK2 (0.54) SYKJAK2CAMK2DCDK2CDK1
Formic Acid SCHEMBL34464810 0.86 JAK2 (0.51) SYKJAK2CAMK2DCDK2CDK1
SCHEMBL34464869 0.85 JAK2 (0.47) SYKJAK2CAMK2DCDK2JAK3
SCHEMBL34464765 0.83 ABL1 (0.60) SYKJAK2CAMK2DCDK2CCNA2
SCHEMBL34464821 0.83 CAMK2D (0.56) JAK2CAMK2DCDK2CDK1CCNA2
SCHEMBL34464794 0.80 JAK2 (0.56) SYKJAK2CAMK2DCDK2JAK3
SCHEMBL34464802 0.79 JAK2 (0.53) JAK2CAMK2DCDK2CDK1JAK3
SCHEMBL34464746 0.79 JAK2 (0.67) SYKJAK2CAMK2DCDK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109690-A1 HDAC6 INHIBITORS AND METHOD OF THEIR USE BAERENKRAFT THERAPEUTICS LLC (US) 2026-04-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109690-A1 HDAC6 INHIBITORS AND METHOD OF THEIR USE HDAC6, HDAC3, HDAC1 SYK 4557/4885JAK2 2639/4885CAMK2D 378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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