SCHEMBL34465698

SCHEMBL34465698

[2H]C([2H])([2H])N(c1ccc(CCOCCNC)cc1)c1ccc(C2CN(CCOc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ WIZ O95785 6/20 0.47
▸ MAPT P10636 3/20 0.45
▸ IKZF2 Q9UKS7 6/20 0.40
▸ CRBN Q96SW2 3/20 0.40
▸ GSPT1 P15170 1/20 0.40
▸ DDB1 Q16531 1/20 0.40
▸ IKZF3 Q9UKT9 1/20 0.40
▸ IKZF1 Q13422 1/20 0.39
▸ TNF P01375 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34466553 0.96 MAPT (0.47) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34466084 0.93 MAPT (0.47) WIZMAPTIKZF2CRBN
SCHEMBL34465878 0.89 CRBN (0.47) IKZF2CRBNGSPT1DDB1IKZF3
SCHEMBL34465859 0.89 IKZF2 (0.47) WIZMAPTIKZF2CRBNIKZF1
SCHEMBL34466436 0.88 WIZ (0.43) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34465616 0.88 CRBN (0.47) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34466532 0.84 MAPT (0.46) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34466511 0.84 WIZ (0.44) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34466106 0.84 MAPT (0.49) WIZMAPTIKZF2CRBNGSPT1
SCHEMBL34466313 0.84 IKZF2 (0.48) WIZMAPTIKZF2CRBNIKZF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF GENOSCO INC (US) 2026-04-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF CRBN, PSMB3, PSMB1 WIZ 1242/4885MAPT 3675/4885IKZF2 1736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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