Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | STK17B | O94768 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3449249 | 0.99 | IGF1R (0.53) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL3447336 | 0.90 | CHEK1 (0.51) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL13310326 | 0.84 | STK17A (0.57) | IGF1RTBK1CHEK1STK17BSTK17A | |
| Hydrochloric Acid SCHEMBL3448826 | 0.83 | STK17A (0.56) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL13311277 | 0.82 | CHEK1 (0.42) | IGF1RCHEK1STK17BSTK17ASIRT5 | |
| SCHEMBL3447534 | 0.81 | CHEK1 (0.54) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL13310320 | 0.79 | STK17A (0.56) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL3451135 | 0.78 | IGF1R (0.53) | IGF1RTBK1CHEK1STK17BSTK17A | |
| Hydrochloric Acid SCHEMBL3449916 | 0.78 | STK17A (0.55) | IGF1RTBK1CHEK1STK17BSTK17A | |
| SCHEMBL3378726 | 0.78 | IGF1R (0.66) | IGF1RCHEK1NTRK2SYKHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | IGF1R 4845/4885TBK1 1295/4885CHEK1 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.