Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448165 | 1.00 | AURKA (0.46) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL13311002 | 0.90 | HDAC1 (0.37) | AURKAGSK3AGSK3BHDAC1HDAC8 | |
| SCHEMBL3448314 | 0.88 | AURKA (0.38) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL3448311 | 0.88 | AURKA (0.38) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL3449053 | 0.87 | RHOA (0.43) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL3449049 | 0.87 | RHOA (0.43) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL3448515 | 0.84 | PIM2 (0.40) | AURKAGSK3AGSK3BRHOACSNK1A1 | |
| SCHEMBL3448518 | 0.84 | PIM2 (0.40) | AURKAGSK3AGSK3BRHOACSNK1A1 | |
| SCHEMBL3449535 | 0.84 | RHOA (0.41) | AURKAGSK3AGSK3BRHOAHDAC1 | |
| SCHEMBL3449530 | 0.84 | RHOA (0.41) | AURKAGSK3AGSK3BRHOAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | AURKA 3990/4885GSK3A 3194/4885GSK3B 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.